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The currency of France (FR) is known as the Euro (EUR).

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Description (Français)


Le bupropion, commercialisé sous les marques Zyban® et Wellbutrin® par le laboratoire GlaxoSmithKline (GSK), est un médicament prescrit en tant qu’aide au sevrage tabagique. Accompagné d’un soutien et d’un suivi psychologique il a obtenu en France une autorisation de mise sur le marche en août 2001 .

Efficacité pour l’aide au sevrage du tabagisme
Une importante étude publiée en 2006 a comparé versus placebo les résultats de 2 molécules, la varenicline (Champix) et le bupropion (Zyban) pour l’aide au sevrage tabagique. A 12 mois, le taux d’abstinence était de 10% pour le placebo, 15% pour le bupropion et 23% pour la varenicline.

Indications
Le bupropion est utilisé pour le sevrage tabagique de personnes dépendantes au tabagisme.

Informations pratiques
Il est délivré uniquement sur ordonnance.

Mode d’action
Le bupropion est un inhibiteur sélectif de la recapture neuronale des catécholamines ce qui fait de lui un psychotrope de type antidépresseur. Il a été commercialisé comme tel aux Etats-Unis avant que l’on découvre ses propriétés pour le sevrage tabagique. Son mode d’action précis dans cette indication reste encore inconnu.

Effets secondaires
Les effets indésirables du bupropion sont nombreux et plus ou moins fréquents. Les plus fréquents sont des troubles digestifs (sécheresse buccale, nausées et vomissements, douleur abdominale, constipation ...), des troubles nerveux (insomnie, maux de tête, ...) ou cutanés (éruption, démangeaisons, sueurs ...).

Contre-indications et Précautions d’emploi
Le bupropion est contre-indiqué en cas d’allergie à l’un de ses constituants, de troubles convulsifs anciens ou présents, de tumeur du système nerveux central, de boulimie ou d’anorexie mentale, de certains troubles psychiatriques et d’insuffisance hépatique grave.

Il est aussi contre-indiqué en cas de sevrage alcoolique ou de sevrage aux benzodiazépines.

Il est déconseillé en cas de grossesse ou d’allaitement.

Interactions médicamenteuses
Le bupropion peut interagir avec de nombreux médicaments. Il est contre-indiqué en cas de traitement aux inhibiteurs de la monoamine oxydase (IMAO).
Note: Your account will be debited in USD when you order Wellbutrin SR with Euro according to your bank's actual exchange rates.

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