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The currency of Italy (IT) is known as the Euro (EUR).

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Descrizione (Italiano)


Il Bupropione, conosciuto anche con i nomi commerciali di Zyban, Wellbutrin, Elontril, è un antidepressivo atipico, di recente commercializzazione in Italia, che agisce inibendo il riassorbimento della dopamina e della noradrenalina. È stato altresì utilizzato, in passato e soprattutto in altri paesi, come molecola antagonista della nicotina; lo scopo principale per il quale tale farmaco è stato studiato e introdotto, riguarda in ogni caso il trattamento della depressione.

Attualmente il ricorso al bupropione è particolarmente indicato, nei casi di quei pazienti che mostrano una resistenza al trattamento con i più diffusi SSRI(gli antidepressivi che agiscono sul sistema serotoninergico). A differenza della maggior parte di questa classe di farmaci, il bupropione si caratterizza per avere ridotti effetti collaterali in particolare per quel che riguarda le disfunzioni sessuali, spesso originate dal trattamento con antidepressivi.

Storia
La sintesi di questa molecola avvenne nel 1966; tuttavia la sua registrazione avvenne nel 1974, a cura dell’attuale GlaxoSmithKline. La sua commercializzazione come antidepressivo fu approvata dalla FDA nel 1985, e seguita però dal ritiro dal commercio a causa di notevoli effetti collaterali, in particolare per quel che riguarda le convulsioni. Il farmaco è stato poi introdotto nuovamente sul mercato, una volta individuate più correttamente le dosi massime terapeutiche che consentono di ridurre al minimo questo tipo di rischio. In seguito, a partire dal 1997, il farmaco è stato approvato anche come supporto nella terapia per interrompere la dipendenza dal fumo; a partire dal 2006, è stato adoperato anche per i disordini umorali stagionali. In Italia, pur essendo già stato introdotto, ma a pagamento, a partire dal 2000, solo dal 2008 si è avviata la diffusione del farmaco sotto copertura totale del SSN.
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